Peptide coupling


Solid-phase synthesis is a common technique for peptide synthesis. Usually, peptides are synthesised from the carbonyl group side (C-terminus) to amino group side (N-terminus) of the amino acid chain in this method, although peptides are biologically synthesised in the opposite direction in cells.

Peptide bond formation is a nucleophilic substitution reaction of an amino group (nucleophile) at a carboxyl group involving a tetrahedral intermediate.

Otto Chemie Pvt Ltd - Manufacturers of Peptide coupling in India.

Peptide coupling

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