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SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27. At low concentrations, it does not inhibit JNK activity.
S 0844 (OTTO) SB 203580, ≥98% (HPLC) Cas 152121-47-6 - used to inhibit MAPK signaling in mouse cortical neurons17 and human hepatocellular carcinoma cell lines.