Fluorescein and Derivatives


There are many fluorescein derivatives. For example, fluorescein isothiocyanate 1, often abbreviated as FITC, is the original fluorescein molecule functionalized with an isothiocyanate group (-N=C=S), replacing a hydrogen atom on the bottom ring of the structure. This derivative is reactive towards primary amine groups of biologically relevant compounds including intracellular proteins to form a thiourea linkage. A succinimidyl ester functional group attached to the fluorescein core, creating NHS-fluorescein, forms another common amine-reactive derivative, yielding more stable amide adducts.

Otto Chemie Pvt Ltd -  Manufacturers of Fluorescein Derivatives Range of compounds in India.

Fluorescein and Derivatives

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