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Synonyms: N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide
NS-398 is a small molecule inhibitor of Cox (cyclooxygenase), relatively selective for Cox-2 (IC50 of 3.8 μM) over Cox-1 (IC50 of > 100 μM). The inflammatory response to injury and stimulus is associated with Cox-2 activity, and this activity is thought to be related to neurotoxicity presented in the progression of cerebral ischemia. NS-398 intervenes upon this progression through inhibition of Cox-2, potentially by suppressing the synthesis of Cox-2 reaction products such as prostanoids and superoxide radicals.
N 0099 (OTTO) NS-398, 98% Cas 123653-11-2 - used in the study of the function of cyclooxygenases.
RIDADR NONH for all modes of transport
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