Natamycin, 95%

N 1373

Pimaricin

7681-93-8

for biochemistry

C33H47NO13

95%

665.73

Bottle / Drum

18%

Pimaricin, Streptomyces chattanoogensis is an antifungal macrolide polyene that binds to cell membrane sterols. Investigations show that the compound predominantly binds to the main sterol in fungal and yeast membranes, ergosterol. Ergosterol is a building block of yeasts and molds, which is responsible for intracellular nutrient transport, and therefore vital for their survival. As ergosterol is not present in the outer membranes of bacteria, these remain unaffected.
Pimarcin has been used as a fungicide in agar media and CYP (cytochrome P450) PimD research proposes that the epoxidiation of Pimaricin occurs through a hydroperoxoferric compound. Pimarcin studies reveal that the regulator PimM binds to eight promoters of Pimarcin genes and its biosynthesis is influenced by a cholesterol oxidase protein encoded by PimE

Pimaricin is an amphoteric antibiotic from Streptomyces chattanoogensis. It is used for a variety of fungal infections, mainly topically. It is used as an ergosterol and cholesterol binding agent to study lipid bilayer dynamics, especially in fungal cells. Pimaricin is used as a fungicide in agar media. It is used to study the pleitropic regulator AdpAch 1 and the gamma-butyrolactone regulatory system of Streptomyces chattanoogensis2.

PackingsPrice (INR)
25 mg 17505.00
100 mg POR
1 gm POR
50 gm POR

Properties

Antibiotics

Powder

Soluble in Acetic acid (5 mg/ml), 0.1%HCOOH in Methanol (1 mg/ml), water (<1 mg/ml), ethanol (<1 mg/ml), DMSO (7 mg/ml), and methanol (~1 mg/ml).

280 °C

952.17 °C at 760 mmHg (Predicted)

Light Sensitive


Safety Information

WGK Germany 3
RTECS TK3325000
Flash Point >110°(230°F)


PackingsPrice (INR)
25 mg 17505.00
100 mg POR
1 gm POR
50 gm POR

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